SAM-e Scientific Name: S-adenosyl methionine (SAM-e)

One of the best studied effects of SAM-e is its potential to enhance neurotransmitter levels. Neurotransmitters are chemicals that carry messages from nerve cells to other cells and then they are re-absorbed into the body. Low levels of the neurotransmitters, dopamine, norepinephrine, and serotonin are associated with depression. SAM-e is known to raise levels of dopamine and norepinephrine in the brain, and it may also accelerate the production, absorption, and re-release of serotonin. Although possible additional antidepressant actions of SAM-e have not been confirmed, results of some studies suggest that SAM-e may increase the sensitivity of receptors that react to these neurotransmitters or improve the ability of neurotransmitters to attach to active receptors. All of these effects are thought to help relieve depression.

GABA Gamma-aminobutyric acid (GABA) is the chief inhibitory neurotransmitter in the mammalian central nervous system. It plays an important role in regulating neuronal excitability throughout the nervous system. GABA is also directly responsible for the regulation of muscle tone.

St. John's Wort -

St. John's wort is a plant with yellow flowers whose medicinal uses were first recorded in ancient Greece. The name St. John's wort apparently refers to John the Baptist, as the plant blooms around the time of the feast of St. John the Baptist in late June.

Common Names—St. John's wort, hypericum, Klamath weed, goat weed

Latin Name—Hypericum perforatum

What It Is Used For

• St. John's wort has been used for centuries to treat mental disorders and nerve pain.
• St. John's wort has also been used as a sedative and a treatment for malaria, as well as a balm for wounds, burns, and insect bites.
• Today, St. John's wort is used by some for depression, anxiety, and/or sleep disorders.